Describe How Cigarette Smoke Influences The Type And Number Of Mutations Present: Cellular Biology Assignment, DU, Australia

University Deakin University
Subject Cellular Biology

QUESTION 1:

Using your knowledge of lung cancer signalling and precision medicine please answer in your own words the following questions in the text box below. Be sure to clearly label the different parts.

Part A. Describe how cigarette smoke influences the type and number of mutations present in lung tumours from NSCLC patients.

Part B. Describe how the PD-L1 ligand is altered in certain lung tumours and how it can affect adaptive immunity

Part C. Discuss which NSCLC patients are suitable for immunotherapy reflecting on the clinical trial data.

QUESTION 2:

Using your knowledge of recording electrical activity and membrane potential please answer in your own words the following questions in the text box below. Be sure to clearly label the different parts.

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Part A. Describe the role of voltage-gated Na+ and K+ channels in an action potential.

Part B. Explain how voltage-gated Na+ and K+ channels respond to depolarization.

QUESTION 3:

Using your knowledge of cell signalling pathways and experimental techniques please analyse the data shown and answer in your own words the questions in the text box below. Be sure to clearly label the different parts.

The datasets below were collected from experiments with a mystery ion channel receptor (ICR).

Interpret the data provided below to determine which of the following: ICRX, ICRY or ICRZ is the most likely identity of the ion channel receptor.

Part A. Name the mystery ion channel receptor ICRX, ICRY or ICRZ.

Part B. Explain how key data findings support your answer.

Part C. Compare the advantages and disadvantages of the experimental techniques used in Experiment 2 and Experiment 3.
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